IL-4 Interleukin-4 Rat Recombinant Protein | Boster PROTP20096 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

IL-4 Interleukin-4 Rat Recombinant Protein

catalog :

PROTP20096

quantity :

5 ug, 20 ug, 1 mg

product information

SKU :

PROTP20096

Product Name :

IL-4 Interleukin-4 Rat Recombinant Protein

Product Page URL :

https://www.bosterbio.comil-4-interleukin-4-rat-recombinant-protein-protp20096-boster.html

Gene Name :

Il4

Size :

5 ug, 20 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Description :

Interleukin-4 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids and having a molecular mass of 14kDa. The IL-4 is purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

Contents :

Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.

AA Sequence and/or Biological Activity :

Amino Acid Sequence:MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS. Biological Activity:Determined by its ability to suppress LPS-induced TNF-alpha and MIP-2 production in mouse splenocytes.

Purification :

Greater than 98.0% as determined by:. (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Storage :

Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

P20096

Gene Full Name :

Interleukin-4

Synonyms :

Interleukin-4;IL-4;B-cell IGG differentiation factor;B-cell growth factor 1;B-cell stimulatory factor 1;BSF-1;Lymphocyte stimulatory factor 1;Il4;Il-4;

Protein Function :

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Subcellular Localization :

Secreted.