Activin-A Rat Recombinant Protein | Boster PROTP18331 product information

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product summary

company name :

Boster

product type :

protein

product name :

Activin-A Rat Recombinant Protein

catalog :

PROTP18331

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTP18331

Product Name :

Activin-A Rat Recombinant Protein

Product Page URL :

https://www.bosterbio.comactivin-a-rat-recombinant-protein-protp18331-boster.html

Gene Name :

Inhba

Size :

2 ug, 10 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Activins are homodimers or heterodimers of the different ? subunit isoforms, part of the TGF? family. Mature Activin A has two 116 amino acids residues ?A subunits (?A-?A). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.

Description :

Active form Activin-A Rat Recombinant produced in e.coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a molecular weight of 26.2kDa. The Active form Activin-A is purified by standard chromatographic techniques.

Source :

E.Coli

Form :

Lyophilized freeze dried powder.

Contents :

Rat Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 0.02% TFA.

AA Sequence and/or Biological Activity :

Amino Acid Sequence:MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS. Biological Activity:Biological activity is assessed by the ability to induce cytoxicity of MPC-11 cells and was found to be 1-1.5 ng/ml corresponding to a specific activity of 666,667-1,000,000 Units/mg.

Purification :

Greater than 95% as obsereved by SDS-PAGE.

Storage :

Lyophilized Activin-A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Activin-A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

P18331

Gene Full Name :

Inhibin beta A chain

Synonyms :

Inhibin beta A chain;Activin beta-A chain;Inhba;

Protein Function :

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subcellular Localization :

Secreted