P-selectin Human Recombinant Protein | Boster PROTP16109 product information

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product summary

company name :

Boster

product type :

protein

product name :

P-selectin Human Recombinant Protein

catalog :

PROTP16109

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTP16109

Product Name :

P-selectin Human Recombinant Protein

Product Page URL :

https://www.bosterbio.comp-selectin-human-recombinant-protein-protp16109-boster.html

Gene Name :

SELP

Size :

2 ug, 10 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: P-Selectin also called Platelet Alpha-Granule Membrane Protein, CD62, and Granulocyte Membrane Protein GRMP belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. Pselectin is expressed transiently on the surface of activated platelets and endothelial cells. P-Selectin is a 140 kDa protein which is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Secreted P-selectin is thought to play a key role in the adhesion of platelets to monocytes and neutrophils during an inflammatory response. P-Selectin is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Levels of P-Selectin may be elevated in a number of pathological conditions.

Description :

P-Selectin Human Recombinant is expressed in E. coli containing 566 amino acids 197-761 fused to an amino terminal hexahistidine tag.

Source :

E. Coli

Form :

Sterile Filtered liquid formulation.

Contents :

P-Selectin is supplied in 50% Glycerol.

Purification :

Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.

Storage :

Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Uniprot ID :

P16109

Gene Full Name :

P-selectin

Synonyms :

P-selectin;CD62 antigen-like family member P;Granule membrane protein 140;GMP-140;Leukocyte-endothelial cell adhesion molecule 3;LECAM3;Platelet activation dependent granule-external membrane protein;PADGEM;CD62P;SELP;GMRP, GRMP;

Protein Function :

Ca (2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.