Recombinant Murine IL-4 Protein | Boster PROTP07750-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

Recombinant Murine IL-4 Protein

catalog :

PROTP07750-1

quantity :

Various Sizes

product information

sku :

PROTP07750-1

status :

Enabled

name :

Recombinant Murine IL-4 Protein

category name :

Proteins, Recombinant Proteins

gene name :

Il4

price various sizes :

5ug / $125 20ug / $230 50ug / $401 100ug / $635 250ug / $1073 500ug / $1805 1mg / $2975

conjugate :

contents :

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

description :

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues.

short description :

description2 :

Amino Acid Sequence . MHIHGCDKN HLREIIGIL NEVTGEGTP CTEMDVPNV LTATKNTTE SELVCRASK VLRIFYLKH GKTPCLKKN SSVLMELQR LFRAFRCLD SSISCTMNE SKSTSLKDF LESLKSIMQ MDYS Biological Activity And Protein Authenticity . The ED 50 was determined by the dose-dependent proliferation of murine HT-2 cells is 2.0 ng/ml, corresponding to a specific activity of 5 x 10 5 units/mg.

size :

Various Sizes

uniprot id :

P07750

host :

form :

Solid; white powder or thin/invisible film

purification :

Above 98% as determined by SDS-PAGE Analysis.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

research category :

Adaptive Immunity, Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology

synonyms :

Interleukin-4;IL-4;B-cell IgG differentiation factor;B-cell growth factor 1;B-cell stimulatory factor 1;BSF-1;IGG1 induction factor;Lymphocyte stimulatory factor 1;Il4;Il-4; BCGF, BCDF, B cell stimulating factor (BSF-1)

gene full name :

Interleukin-4

protein function :

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241).

subcellular localization :

Secreted.

source :

E. Coli

last modified :

2/15/19 23:59