CTSD Cathepsin-D Human Recombinant Protein | Boster PROTP07339 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

CTSD Cathepsin-D Human Recombinant Protein

catalog :

PROTP07339

quantity :

2 ug, 5 ug, 10 ug

product information

SKU :

PROTP07339

Product Name :

CTSD Cathepsin-D Human Recombinant Protein

Product Page URL :

https://www.bosterbio.comctsd-cathepsin-d-human-recombinant-protein-protp07339-boster.html

Gene Name :

CTSD

Size :

2 ug, 5 ug, 10 ug

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.

Description :

Catheprsin D Human Recombinant full length protein expressed in E.coli, shows a 48 kDa band on SDS-PAGE. The Catheprsin D is purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered clear solution.

Contents :

Cathepsin D at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Storage :

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.

Uniprot ID :

P07339

Gene Full Name :

Cathepsin D

Synonyms :

Cathepsin D;3.4.23.5;Cathepsin D light chain;Cathepsin D heavy chain;CTSD;CPSD;

Protein Function :

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Subcellular Localization :

Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).

Tissue Specificity :

Expressed in the aorta extrcellular space (at protein level).