MPO Myeloperoxidase Human protein | Boster PROTP05164 product information

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product summary

company name :

Boster

product type :

protein

product name :

MPO Myeloperoxidase Human protein

catalog :

PROTP05164

quantity :

5 ug, 25 ug, 1 mg

product information

SKU :

PROTP05164

Product Name :

MPO Myeloperoxidase Human protein

Product Page URL :

https://www.bosterbio.commpo-myeloperoxidase-human-protein-protp05164-boster.html

Gene Name :

MPO

Size :

5 ug, 25 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Myeloperoxidase is an important enzyme used by granulocytes during phagocytic lysis of foreign particles engulfed. In normal tissues and in a variety of myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is not observed in the neoplastic cells of a wide variety of epithelial tumors and sarcomas. MPO is useful in differentiating between myeloid and lymphoid leukemias.

Description :

MPO is a natural protein having a molecular mass of 150kDa containing 2 subunits each of a heavy chain with 64kDa and a light chain with 13kDa. MPO is isolated from human peripheral blood polymorphonuclear leukocytes.

Source :

Human peripheral blood polymorphonuclear leukocytes.

Form :

Sterile filtered colorless solution.

Contents :

MPO solution is supplied in 20mM HEPES buffer pH-7.5, 200mM NaCl and 20% glycerol.

Purification :

Greater than 80% as determined by SDS-PAGE.

Storage :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Uniprot ID :

P05164

Gene Full Name :

Myeloperoxidase

Synonyms :

Myeloperoxidase;MPO;1.11.2.2;Myeloperoxidase;89 kDa myeloperoxidase;84 kDa myeloperoxidase;Myeloperoxidase light chain;Myeloperoxidase heavy chain;MPO;

Protein Function :

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subcellular Localization :

Lysosome