AHSG Alpha-2-HS-Glycoprotein Human Recombinant Protein HEK | Boster PROTP02765 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

AHSG Alpha-2-HS-Glycoprotein Human Recombinant Protein HEK

catalog :

PROTP02765

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTP02765

Product Name :

AHSG Alpha-2-HS-Glycoprotein Human Recombinant Protein HEK

Product Page URL :

https://www.bosterbio.comahsg-alpha-2-hs-glycoprotein-human-recombinant-protein-hek-protp02765-boster.html

Gene Name :

AHSG

Size :

2 ug, 10 ug, 1 mg

Introduction :

Introduction: Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains. Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the receptor (IR). Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation. Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.

Description :

AHSG Human Recombinant produced by transfected human cells is a single polypeptide chain containing 357 amino acids (19-367). AHSG is fused to an 8 amino acid His-tag at C-terminus purified by proprietary chromatographic techniques.

Source :

HEK293 cells.

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

AA Sequence and/or Biological Activity :

Sequence:APHGPGLIYRQPNCDDPETEEAALVAIDYI
NQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLET
TCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFS
VVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAK
AALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVS
GTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEV
AVTCTVFQTQPVTSQPQPEGANEAVPTPVVDPDAPPSPP
LGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFM
GVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG
RIRHFKVVDHHHHHH.
Amino Acid

Purification :

Greater than 95% as determined by SDS-PAGE.

Storage :

Lyophilized AHSG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution AHSG should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Uniprot ID :

P02765

Synonyms :

Alpha-2-HS-glycoprotein;Alpha-2-Z-globulin;Ba-alpha-2-glycoprotein;Fetuin-A;Alpha-2-HS-glycoprotein chain A;Alpha-2-HS-glycoprotein chain B;AHSG;FETUA;PRO2743;