Recombinant Human sIL-2R Alpha Protein | Boster PROTP01589-2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

Recombinant Human sIL-2R Alpha Protein

catalog :

PROTP01589-2

quantity :

Various Sizes

product information

sku :

PROTP01589-2

status :

Enabled

name :

Recombinant Human sIL-2R Alpha Protein

category name :

Proteins, Recombinant Proteins

gene name :

IL2RA

price various sizes :

5Âµg / $125 25Âµg / $230 100Âµg / $590 500Âµg / $1650 1mg / $2750

conjugate :

contents :

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

description :

The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R , IL-2R , and IL-2R . The IL-2R is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R releases the entire extracellular domain of IL-2R thereby generating a 219 amino acid soluble protein called soluble IL-2R (sIL-2R ). The homodimeric form binds IL-2 (KD=10nM) and facilitates IL-2 signaling. The secreted sIL-2R is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R . Due to glycosylation, IL-2R has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

short description :

description2 :

Biological Activity And Protein Authenticity . Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. In the presence of 1 ng/ml of recombinant IL-2, the expected ED 50 for this effect is between 0.5 - 1.5 ug/ml.

size :

Various Sizes

uniprot id :

P01589

host :

form :

Solid; white powder or thin/invisible film

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

research category :

Adaptive Immunity, Cytokines, Immunology, Innate Immunity, Interleukins, T Cells

synonyms :

Interleukin-2 receptor subunit alpha;IL-2 receptor subunit alpha;IL-2-RA;IL-2R subunit alpha;IL2-RA;TAC antigen;p55;CD25;IL2RA; soluble IL-2 receptor, TAC-antigen, CD25 antigen

gene full name :

Interleukin-2 receptor subunit alpha

protein function :

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

subcellular localization :

Membrane; Single-pass type I membrane protein.

source :

(BTI-Tn-5B1-4) Hi-5 Insect cells*

last modified :

2/15/19 23:59