Recombinant Human TNF-Alpha Protein | Boster PROTP01375-5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

Recombinant Human TNF-Alpha Protein

catalog :

PROTP01375-5

quantity :

Various Sizes

product information

sku :

PROTP01375-5

status :

Enabled

name :

Recombinant Human TNF-Alpha Protein

category name :

Proteins, Recombinant Proteins

gene name :

TNF

price various sizes :

10ug / $125 50ug / $230 100ug / $320 250ug / $522 500ug / $860 1mg / $1400

conjugate :

contents :

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

description :

TNF- is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF- is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF- also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF- is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

short description :

description2 :

Biological Activity And Protein Authenticity . The ED 50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is 0.05 ng/ml, corresponding to a specific activity of 2 x 10 7 units/mg.

size :

Various Sizes

uniprot id :

P01375

host :

form :

Solid; white powder or thin/invisible film

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

research category :

Atherosclerosis, Cancer, Cardiovascular, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Metabolism, Signal Transduction, Tnf Superfamily, Vascular Inflammation

synonyms :

Tumor necrosis factor;Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a;Tumor necrosis factor, membrane form;N-terminal fragment;NTF;Intracellular domain 1;ICD1;Intracellular domain 2;ICD2;C-domain 1;C-domain 2;Tumor necrosis factor, soluble form;TNF;TNFA, TNFSF2; Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin

gene full name :

Tumor necrosis factor

protein function :

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

subcellular localization :

Cell membrane ; Single-pass type II membrane protein .

source :

E. Coli

last modified :

2/15/19 23:59