b-NGF beta Nerve Growth Factor Human Recombinant Protein, HEK

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product summary

company name :

Boster

product type :

protein

product name :

b-NGF beta Nerve Growth Factor Human Recombinant Protein, HEK

catalog :

PROTP01138

quantity :

5 ug, 20 ug, 1 mg

product information

SKU :

PROTP01138

Product Name :

b-NGF beta Nerve Growth Factor Human Recombinant Protein, HEK

Product Page URL :

https://www.bosterbio.comb-ngf-beta-nerve-growth-factor-human-recombinant-protein-hek-protp01138-boster.html

Gene Name :

NGF

Size :

5 ug, 20 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: NGF-beta has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

Description :

Beta-NGF Human Recombinant produced in HEK cells is a non-glycosylated non-disulfide linked homodimer, having a total molecular weight of 13kDa. The b-NGF is purified by proprietary chromatographic techniques.

Source :

HEK.

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

Contents :

The b-NGF was lyophilized from 1mg/ml in 1xPBS.

AA Sequence and/or Biological Activity :

Biological Activity: The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line)

Purification :

Greater than 95% as obsereved by SDS-PAGE.

Storage :

Lyophilized b-NGF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution b-NGF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

P01138

Gene Full Name :

Beta-nerve growth factor

Synonyms :

Beta-nerve growth factor;Beta-NGF;NGF;NGFB;

Protein Function :

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).

Subcellular Localization :

Secreted.