TGF-b-1 Transforming Growth Factor-Beta 1 Human Recombinant Protein, CHO

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product summary

company name :

Boster

product type :

protein

product name :

TGF-b-1 Transforming Growth Factor-Beta 1 Human Recombinant Protein, CHO

catalog :

PROTP01137-5

quantity :

2 ug, 10 ug, 1 mg

product information

sku :

PROTP01137-5

status :

Enabled

name :

TGF-b-1 Transforming Growth Factor-Beta 1 Human Recombinant Protein, CHO

gene name :

TGFB1

price various sizes :

Sample: 2ug / $153 Regular: 10ug / $230 Bulk: 1mg / $4233

conjugate :

description :

TGFB1 Human Recombinant produced in CHO cells is a homodimeric polypeptide chain containing 2 x 112 amino acids and having a total molecular mass of 25kDa.

short description :

TGFB25kDa.

description1 :

Introduction . Transforming growth factor betas (TGFBetas) mediate many cell-cell interactions that occur during embryonic development. Three TGFBetas have been identified in mammals. TGFBeta1, TGFBeta2 and TGFBeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

description2 :

Amino Acid Sequence ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

size :

2 ug, 10 ug, 1 mg

uniprot id :

P01137

host :

form :

Sterile filtered colorless solution.

purification :

Greater than 95% as determined by SDS-PAGE.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

synonyms :

Transforming growth factor beta-1;TGF-beta-1;Latency-associated peptide;LAP;TGFB1;TGFB;

gene full name :

Transforming growth factor beta-1

protein function :

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

subcellular localization :

Secreted, extracellular space, extracellular matrix

tissue specificity :

Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.

source :

Chinese Hamster Ovary cells.

last modified :

2/18/19 20:29