PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein

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product summary

company name :

Boster

product type :

protein

product name :

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein

catalog :

PROTP01127-2

quantity :

2 ug, 10 ug, 1 mg

product information

sku :

PROTP01127-2

status :

Enabled

name :

PDGF-BB Platelet-Derived Growth Factor BB Human Recombinant Protein

gene name :

PDGFB

price various sizes :

Sample: 2ug / $153 Regular: 10ug / $230 Bulk: 1mg / $3183

conjugate :

description :

Platelet-Derived Growth Factor BB Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2x109 amino acids (218 amino acids in total) and having a molecular mass of 24.3 kDa. PDGF-BB is purified by proprietary chromatographic techniques.

short description :

description1 :

Introduction . PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

description2 :

Amino Acid Sequence SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT. Biological Activity Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED 50

size :

2 ug, 10 ug, 1 mg

uniprot id :

P01127

host :

form :

Sterile Filtered White lyophilized (freeze-dried) powder.

purification :

Greater than 95.0% as determined by:. (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

synonyms :

Platelet-derived growth factor subunit B;PDGF subunit B;PDGF-2;Platelet-derived growth factor B chain;Platelet-derived growth factor beta polypeptide;Proto-oncogene c-Sis;Becaplermin;PDGFB;PDGF2, SIS;

gene full name :

Platelet-derived growth factor subunit B

protein function :

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

subcellular localization :

Secreted. Released by platelets upon wounding.

tissue specificity :

Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.

source :

E. Coli

last modified :

2/18/19 20:29