TIMM8A Translocase of Inner Mitochondrial Membrane 8 Homolog A Human Recombinant Protein

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product summary

company name :

Boster

product type :

protein

product name :

TIMM8A Translocase of Inner Mitochondrial Membrane 8 Homolog A Human Recombinant Protein

catalog :

PROTO60220

quantity :

5 ug, 20 ug, 1 mg

product information

sku :

PROTO60220

status :

Enabled

name :

TIMM8A Translocase of Inner Mitochondrial Membrane 8 Homolog A Human Recombinant Protein

gene name :

TIMM8A

price various sizes :

Sample: 5ug / $153 Regular: 20ug / $230 Bulk: 1mg / $2483

conjugate :

contents :

The TIMM8A solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.

description :

TIMM8A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-97) and having a molecular mass of 13.4 kDa. TIMM8A is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

short description :

description1 :

Introduction . Translocase of Inner Mitochondrial Membrane 8 Homolog A (TIMM8A) takes part in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial. TIMM8A plays a role as a chaperone-like protein which protects the hydrophobic precursors from aggregation and leads them through the mitochondrial intermembrane space. TIMM8A is essential for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Defects in TIMM8A cause Jensen syndrome. TIMM8A and TIMM13, forms a 70 kDa heterohexamer.

description2 :

Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMDSSSSS SAAGLGAVDP QLQHFIEVET QKQRFQQLVH QMTELCWEKC MDKPGPKLDS RAEACFVNCV ERFIDTSQFI LNRLEQTQKS KPVFSESLSD.

size :

5 ug, 20 ug, 1 mg

uniprot id :

O60220

host :

form :

Sterile Filtered colorless solution.

purification :

Greater than 90.0% as determined by SDS-PAGE.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

synonyms :

Mitochondrial import inner membrane translocase subunit Tim8 A;Deafness dystonia protein 1;X-linked deafness dystonia protein;TIMM8A;DDP, DDP1, TIM8A;

gene full name :

Mitochondrial import inner membrane translocase subunit Tim8 A

protein function :

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.

subcellular localization :

Mitochondrion inner membrane

tissue specificity :

Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart.

source :

E. Coli

last modified :

4/18/19 6:56