ADAM12 A Disintegrin and Metalloproteinase Domain 12 S-Isoform Human Recombinant Protein

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product summary

company name :

Boster

product type :

protein

product name :

ADAM12 A Disintegrin and Metalloproteinase Domain 12 S-Isoform Human Recombinant Protein

catalog :

PROTO43184

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTO43184

Product Name :

ADAM12 A Disintegrin and Metalloproteinase Domain 12 S-Isoform Human Recombinant Protein

Product Page URL :

https://www.bosterbio.comadam12-a-disintegrin-and-metalloproteinase-domain-12-s-isoform-human-recombinant-protein-proto43184-boster.html

Gene Name :

ADAM12

Size :

2 ug, 10 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis. ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).

Description :

ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa.

Source :

E. Coli

Form :

Sterile Filtered colorless solution.

Contents :

The ADAM12 solution contains 25mM Sodium Acetate pH 4.8 and 50% Glycerol.

Purification :

Greater than 95.0% as determined by SDS-PAGE.

Storage :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Uniprot ID :

O43184

Gene Full Name :

Disintegrin and metalloproteinase domain-containing protein 12

Synonyms :

Disintegrin and metalloproteinase domain-containing protein 12;ADAM 12;3.4.24.-;Meltrin-alpha;ADAM12;MLTN;UNQ346/PRO545;

Protein Function :

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Tissue Specificity :

Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.