BD-2 Beta Defensin-2 Mouse Recombinant Protein | Boster PROTO15263 product information

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product summary

company name :

Boster

product type :

protein

product name :

BD-2 Beta Defensin-2 Mouse Recombinant Protein

catalog :

PROTO15263

quantity :

5 ug, 20 ug, 1 mg

product information

sku :

PROTO15263

status :

Enabled

name :

BD-2 Beta Defensin-2 Mouse Recombinant Protein

gene name :

DEFB4ADEFB4B

price various sizes :

Sample: 5ug / $153 Regular: 20ug / $230 Bulk: 1mg / $2483

conjugate :

description :

Beta Defensin-2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 51 amino acids and having a molecular mass of 5.5kDa. The BD-2 is purified by proprietary chromatographic techniques.

short description :

Beta Defensin-2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 5.5kDa. The BD-2 is purified by proprietary chromatographic techniques.

description1 :

Introduction . The Defensin family are highly similar in their protein sequence and are microbicidal cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. BBeta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. Variation in human Beta Defensin-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human Beta Defensin-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. The expression of Human BD1 is correlated with induction profiles in gingival keratinocytes. The level of expression of human DEFB1 mRNA is lower than that of human BD3 and human BD-2 in reconstructed epidermis. Human BD1 is down-regulated in human prostatic and renal carcinomas.

description2 :

Amino Acid Sequence AVGSLKSIGY EAELDHCHTN GGYCVRAICP PSARRPGSCF PEKNPCCKYM K. Biological Activity Determined by the ability to chemoattract immature human dendritic cells at a concentration of 10-100ng/ml.

size :

5 ug, 20 ug, 1 mg

uniprot id :

O15263

host :

form :

Sterile Filtered White lyophilized (freeze-dried) powder.

purification :

Greater than 98.0% as determined by:. (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

synonyms :

Beta-defensin 4A;Beta-defensin 2;BD-2;hBD-2;Defensin, beta 2;Skin-antimicrobial peptide 1;SAP1;DEFB4A;DEFB102, DEFB2, DEFB4;DEFB4B;

gene full name :

Beta-defensin 4A

protein function :

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).

subcellular localization :

Secreted.

tissue specificity :

Expressed in the skin and respiratory tract.

source :

E. Coli

last modified :

2/18/19 20:29