Anti-Transglutaminase 2/TGM2 Antibody Picoband™ | Boster PB9448 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Transglutaminase 2/TGM2 Antibody Picoband™

catalog :

PB9448

quantity :

100μg/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

SKU :

PB9448

Product Name :

Anti-Transglutaminase 2/TGM2 Antibody Picoband™

Size :

100μg/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

IHC, WB

Application Details :

Immunohistochemistry (Frozen Section), 0.5-1µg/ml, Human, Mouse, RatImmunohistochemistry (Paraffin-embedded Section), 0.5-1µg/ml, Human, Mouse, Rat, By Heat. Western blot, 0.1-0.5µg/ml, Human, Rat.

Application Notes :

WB: The detection limit for TGM2 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Transglutaminase 2/TGM2 Antibody Picoband™ catalog # PB9448. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

TGM2

Uniprot ID :

P21980

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human TGM2 (7-34aa LERCDLELETNGRDHHTADLCREKLVVR), different from the related mouse sequence by five amino acids.

Form :

Lyophilized

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Cross-reactivity :

No cross reactivity with other proteins

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Gene Full Name :

Protein-glutamine gamma-glutamyltransferase 2

Synonyms :

Protein-glutamine gamma-glutamyltransferase 2; 2.3.2.13; Tissue transglutaminase; Transglutaminase C; TG (C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2; TGM2;

Protein Name :

Protein-glutamine gamma-glutamyltransferase 2

Molecular Weight :

77329 MW

Protein Function :

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and IHC(F).

Sequence Similarities :

Belongs to the transglutaminase superfamily. Transglutaminase family.

Background :

Tissue transglutaminase, also called TGC, is a 78-kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. By fluorescence in situ hybridization (FISH), this gene is mapped in 20q11.23. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.

Research Category :

Amino Acid Metabolism, Amino Acids, Apoptosis, Associated Proteins, Autoimmune, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Biology, Immune System Diseases, Immunology, Intracellular, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Signal Transduction, Signaling Pathway