Anti-Adiponectin Receptor 1/ADIPOR1 Antibody Picoband™

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Adiponectin Receptor 1/ADIPOR1 Antibody Picoband™

catalog :

PB9418

quantity :

100μg/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunocytochemistry

product information

SKU :

PB9418

Product Name :

Anti-Adiponectin Receptor 1/ADIPOR1 Antibody Picoband™

Size :

100μg/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Rat

Predicted Reactivity :

Hamster

Application(s) :

IF, ICC, WB

Application Details :

Western blot, 0.1-0.5µg/ml, Human, Rat. Immunocytochemistry/Immunofluorescence, 2µg/ml, Human.

Application Notes :

WB: The detection limit for ADIPOR1 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Adiponectin Receptor 1/ADIPOR1 Antibody Picoband™ catalog # PB9418. Tested in IF, ICC, WB applications. This antibody reacts with Human, Rat.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

ADIPOR1

Uniprot ID :

Q96A54

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human ADIPOR1 (51-78aa EQTCPVPQEEEEEVRVLTLPLQAHHAME), different from the related mouse sequence by two amino acids.

Form :

Lyophilized

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Cross-reactivity :

No cross reactivity with other proteins

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Gene Full Name :

Adiponectin receptor protein 1

Synonyms :

Adiponectin receptor protein 1; Progestin and adipoQ receptor family member I; ADIPOR1; PAQR1 , TESBP1A; CGI-45;

Protein Name :

Adiponectin receptor protein 1

Molecular Weight :

42616 MW

Protein Function :

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Subcellular Localization :

Cell membrane ; Multi-pass membrane protein. Localized to the cell membrane and intracellular organelles.

Tissue Specificity :

Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for ICC.

Sequence Similarities :

Belongs to the ADIPOR family.

Background :

ADIPOR1 is known as Adiponectin receptor protein 1. This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene.

Research Category :

Cardiovascular, Growth Factors/Hormones, Lipids / Lipoproteins, Signal Transduction