antibody

Anti-TrkB/NTRK2 Antibody Picoband‚Ñ¢

PB9378

10 ug sample

99 USD

polyclonal

domestic rabbit

nonconjugated

human, mouse, rat

1

Anti-TrkB/NTRK2 Antibody Picoband‚Ñ¢

anti-trkb-picoband-trade-antibody-pb9378-boster

Primary Antibodies

NTRK2

315

10 ug sample

99 USD

Full size

315

Full size carrier free

365

Polyclonal

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Boster Bio Anti-TrkB/NTRK2 Antibody Picoband catalog # PB9378. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Boster Bio Anti-TrkB/NTRK2 Antibody Picoband catalog # PB9378. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

100μg/vial

Q16620

Rabbit

E.coli-derived human TrkB recombinant protein (Position: E66-E242). Human TrkB shares 91.5% and 89.8% amino acid (aa) sequence identity with mouse and rat TrkB, respectively.

Lyophilized

Immunogen affinity purified.

Store at -20ÀöC for one year from date of receipt. After reconstitution, at 4ÀöC for one month. It can also be aliquotted and stored frozen at -20ÀöC for six months. Avoid repeated freeze-thaw cycles.

No cross reactivity with other proteins.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Western blot, 0.1-0.5ug/ml, Mouse, Rat, Human.

WB

Human,Mouse,Rat

/antibody/pb9378-1-WB-anti-trkb-antibody.jpg

Anti-TrkB Picoband antibody PB9378 Western blotting. All lanes: Anti TrkB (PB9378) at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 50ug. Lane 2: Mouse Brain Tissue Lysate at 50ug. Predicted bind size: 92KD. Observed bind size: 120KD

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4/27/15 19:03

3/2/22 2:55

Anti-TrkB/NTRK2 Antibody Picoband Bosterbio PB9378

Anti-TrkB/NTRK2 Antibody Picoband

Boster Bio Anti-TrkB/NTRK2 Antibody Picoband catalog # PB9378. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100ug/vial in Lyophilized form antibody.

WB: The detection limit for TrkB is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

100

TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival.

sc 11 sc 11 G sc 119 sc 119 X sc 12 sc 12 G sc 135645 sc 136990 sc 136991 sc 139 sc 20542 sc 25103 sc 25103 R sc 377218 sc 414 sc 514932 sc 514932 X sc 7268 sc 7987 sc 7987 R sc 8058 sc 8316

Neuroscience,Oncoproteins,Oncoproteins/Suppressors,Pathways And Processes

BDNF/NT-3 growth factors receptor;2.7.10.1;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B;NTRK2;TRKB;

BDNF/NT-3 growth factors receptor

91999 MW

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin- dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Cell membrane; Single-pass type I membrane protein. Endosome membrane ; Single-pass type I membrane protein . Internalized to endosomes upon ligand-binding.

Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.

BDNF/NT-3 growth factors receptor

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

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