Anti-Angiotensin Converting Enzyme 1/ACE Antibody | Boster PA2196-2 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Angiotensin Converting Enzyme 1/ACE Antibody

catalog :

PA2196-2

quantity :

100μg/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

SKU :

PA2196-2

Product Name :

Anti-Angiotensin Converting Enzyme 1/ACE Antibody

Size :

100μg/vial

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse

Application(s) :

Application Details :

Western blot, 0.1-0.5µg/ml, Human, Mouse.

Application Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Angiotensin Converting Enzyme 1/ACE Antibody catalog # PA2196-2. Tested in WB applications. This antibody reacts with Human, Mouse.

Concentration :

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Gene Name :

ACE

Uniprot ID :

P12821

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human Angiotensin Converting Enzyme 1 (130-144aa ANLPLAKRQQYNALL), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Form :

Lyophilized

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Cross-reactivity :

No cross reactivity with other proteins

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Gene Full Name :

Angiotensin-converting enzyme

Synonyms :

Angiotensin-converting enzyme; ACE; 3.2.1.-; 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143; Angiotensin-converting enzyme, soluble form; ACE; DCP, DCP1;

Protein Name :

Angiotensin-converting enzyme

Molecular Weight :

149715 MW

Protein Function :

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

Subcellular Localization :

Angiotensin-converting enzyme, soluble form: Secreted.

Tissue Specificity :

Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

Sequence Similarities :

Belongs to the peptidase M2 family.

Background :

Angiotensin I converting enzyme (ACE), also called DCP or CD143 is a zinc-containing dipeptidyl carboxypeptidase widely distributed in mammalian tissues and is though to play a critical role in blood pressure regulation. This gene is mapped to 17q23.3. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies.

Research Category :

Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Cofactors, Vitamins / Minerals, Hematopoietic Progenitors, Metabolism, Metabolism Processes, Metalloprotease, Pathways And Processes, Proteolysis / Ubiquitin, Proteolytic Enzymes, Response To Hypoxia, Serum Proteins, Signal Transduction, Stem Cells, Surface Molecules, Vasculature, Vitamins / Minerals