Anti-OPG Antibody | Boster PA2118 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-OPG Antibody

catalog :

PA2118

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

PA2118

name :

Anti-OPG Antibody

price :

200 USD

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human Osteoprotegerin(369-389aa IRFLHSFTMYKLYQKLFLEMI), different from the related rat sequence by one amino acid, and different from the related mouse sequence by two amino acids.

form :

Lyophilized

host :

Rabbit

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

purification :

Immunogen affinity purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11B(TNFRSF11B) detection. Tested with WB in Human;Mouse;Rat.

size :

100 ug/vial

reactivity :

Human; Mouse; Rat

applications :

background :

Tumor necrosis factor receptor superfamily member 11B(TNFRSF11B), also known as OPG, is a protein that in humans is encoded by the TNFRSF11B gene. OPG is a cytokine receptor, and a member of the tumor necrosis factor(TNF) receptor superfamily. By analysis of radiation hybrids, TNFRSF11B gene was mapped to chromosome 8q24. OPG is a decoy receptor for the receptor activator of nuclear factor kappa B ligand(RANKL). By binding RANKL, OPG inhibits nuclear kappa B(NF-kappa B) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. OPG binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and ostepclast precursors.

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cross reactivity :

No cross reactivity with other proteins

gene full name :

Tumor necrosis factor receptor superfamily member 11B

gene name :

TNFRSF11B

protein function :

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

protein name :

Tumor necrosis factor receptor superfamily member 11B

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

research category :

cardiovascular blood immunology innate immunity cytokines tnf superfamily signal transduction cytoskeleton / ecm extracellular matrix structures bone cardiovascular atherosclerosis vascular inflammation inflammatory mediators metabolism types of disease obesity

sequence similarities :

Contains 2 death domains.

storage :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Secreted.

synonyms :

Tumor necrosis factor receptor superfamily member 11B;Osteoclastogenesis inhibitory factor;Osteoprotegerin;TNFRSF11B;OCIF, OPG;

tissue specificity :

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

uniprot id :

O00300