Anti-PECAM-1/CD31 Antibody | Boster PA1950 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-PECAM-1/CD31 Antibody

catalog :

PA1950

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

product information

sku :

PA1950

name :

Anti-PECAM-1/CD31 Antibody

price :

200 USD

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of mouse CD31(547-566aa HNKQASKKQEGQYYCTASNR).

form :

Lyophilized

host :

Rabbit

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

purification :

Immunogen affinity purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Platelet endothelial cell adhesion molecule(PECAM1) detection. Tested with WB in Mouse.

size :

100 ug/vial

reactivity :

Mouse

applications :

background :

PECAM-1(Platelet endothelial cell adhesion molecule), also known as cluster of differentiation 31(CD31) is a protein that in human is encoded by the PECAM1 gene found on chromosome 17. PECAM1 is a member of the immunoglobulin(Ig) superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and particular T-cell subsets. Using a PCR-based analysis of somatic cell hybrids, Gumina et al.(1996) mapped PECAM1 to chromosome 17 in the region 17q23-qter. Several adhesion molecules expressed on platelets and endothelium also localized to 17q. Xie and Muller(1996) mapped the Pecam1 gene to mouse chromosome 6, region F3-G1, by fluorescence in situ hybridization. PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions, and PECAM-1 plays a key role in removing aged neutrophils from the body.

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cross reactivity :

No cross reactivity with other proteins

gene full name :

Platelet endothelial cell adhesion molecule

gene name :

PECAM1; Pecam1

protein function :

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation (By similarity). Induces susceptibility to atherosclerosis.

protein name :

Platelet endothelial cell adhesion molecule

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

research category :

signal transduction cytoskeleton / ecm cell adhesion cell adhesion molecules endothelial cardiovascular angiogenesis angiogenic factors immunology cell type markers kits/ lysates/ other elisa kits cd markers elisa kits atherosclerotic proteins elisa kits

sequence similarities :

Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

storage :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor . Cell junction. Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

synonyms :

Platelet endothelial cell adhesion molecule;PECAM-1;CD31;Pecam1;Pecam, Pecam-1;

tissue specificity :

Isoform 1 and isoform 3 are expressed in lung and platelets.

uniprot id :

Q08481