Anti-CD11b Antibody | Boster PA1943 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-CD11b Antibody

catalog :

PA1943

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

product information

sku :

PA1943

name :

Anti-CD11b Antibody

price :

200 USD

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of mouse CD11b(1135-1153aa KRQYKDMMNEAAPQDAPPQ).

form :

Lyophilized

host :

Rabbit

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

purification :

Immunogen affinity purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Integrin alpha-M(ITGAM) detection. Tested with WB in Mouse.

size :

100 ug/vial

reactivity :

Mouse

applications :

background :

ITGAM(Integrin Alpha-M), also called CD11B or Mo1 ALPHA SUBUNIT(MO1A), is one protein subunit that forms the heterodimeric integrin alpha-M beta-2(alphaMbeta2) molecule. A major surface antigen family on human leukocytes includes complement receptor type 3(CR3A; also called ITGAM, Mac1, or Mo1), lymphocyte function-associated(LFA) antigen type 1(ITGAL), and p150, 95(ITGAX). By in situ hybridization, Corbi et al.(1988) demonstrated that the genes encoding the alpha subunits of LFA1(ITGAL), Mac1, and p150, 95(ITGAX), all of which are involved in leukocyte adhesion, constitute a cluster on 16p13.1-p11. Callen et al.(1991) narrowed the assignment to 16p11.2. Inflammation plays an essential role in the initiation and progression of atherosclerosis. Simon et al.(2000) presented evidence that it also has a role in vascular repair after mechanical arterial injury(i.e., percutaneous transluminal coronary angioplasty, or PTCA).

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cross reactivity :

No cross reactivity with other proteins

gene full name :

Integrin alpha-M

gene name :

ITGAM; Itgam

protein function :

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.

protein name :

Integrin alpha-M

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

research category :

ITGAM

sequence similarities :

Belongs to the integrin alpha chain family.

storage :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Membrane; Single-pass type I membrane protein.

synonyms :

Integrin alpha-M;CD11 antigen-like family member B;CR-3 alpha chain;Cell surface glycoprotein MAC-1 subunit alpha;Leukocyte adhesion receptor MO1;CD11b;Itgam;

tissue specificity :

Predominantly expressed in monocytes and granulocytes.

uniprot id :

P05555