Anti-VCAM-1 Antibody | Boster PA1873 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-VCAM-1 Antibody

catalog :

PA1873

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

product information

sku :

PA1873

name :

Anti-VCAM-1 Antibody

price :

200 USD

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of mouse VCAM1(653-671aa YTIRQAQLQDAGIYECESK), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

form :

Lyophilized

host :

Rabbit

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

purification :

Immunogen affinity purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Vascular cell adhesion protein 1(VCAM1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

size :

100 ug/vial

reactivity :

Human; Mouse; Rat

applications :

IHC-P; WB

background :

CD106(cluster of differentiation 106) also known as vascular cell adhesion molecule 1(VCAM-1),is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. Cybulsky et al.(1991) mapped the VCAM1 gene to chromosome 1 by Southern analysis of somatic cell hybrids. Kumar et al.(1994) mapped the murine Vcam1 gene to chromosome 3 near Amy1.VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes,monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated.

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cross reactivity :

No cross reactivity with other proteins

gene full name :

Vascular cell adhesion protein 1

gene name :

VCAM1; Vcam1

protein function :

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

protein name :

Vascular cell adhesion protein 1

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

research category :

signal transduction cytoskeleton / ecm cell adhesion cell adhesion molecules vascular signal transduction endothelial neuroscience neurology process neural signal transduction stem cells mesenchymal stem cells surface molecules cancer invasion/microenvironment cardiovascular atherosclerosis vascular inflammation leukocyte recruitment kits/ lysates/ other elisa kits adhesion molecules elisa kits atherosclerotic proteins elisa kits

sequence similarities :

Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

storage :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

synonyms :

Vascular cell adhesion protein 1;V-CAM 1;VCAM-1;CD106;Vcam1;Vcam-1;

tissue specificity :

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

uniprot id :

P29533