Anti-Peroxiredoxin 1/PRDX1 Antibody | Boster PA1772 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Peroxiredoxin 1/PRDX1 Antibody

catalog :

PA1772

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

PA1772

status :

Enabled

name :

Anti-Peroxiredoxin 1/PRDX1 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

PRDX1

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for Peroxiredoxin 1/PRDX1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. Peroxiredoxin 1/PRDX1 information: Molecular Weight: 22110 MW; Subcellular Localization: Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

short description :

Rabbit IgG polyclonal antibody for Peroxiredoxin-1(PRDX1) detection. Tested with WB in Human;Mouse;Rat.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

Q06830

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 1(185-199aa KPDVQKSKEYFSKQK), different from the related rat and mouse sequences by one amino acid.

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Human, Rat, Mouse.

applications :

reactivity :

Human, Mouse, Rat

predicted reactivity :

Hamster

image labels :

Anti-Peroxiredoxin 1 antibody, PA1772, Western blotting. All lanes: Anti Peroxiredoxin 1 (PA1772) at 0.5ug/ml. Lane 1: U87 Whole Cell Lysate at 40ug. Lane 2: 563T Whole Cell Lysate at 40ug. Lane 3: Rat Brain Tissue Lysate at 50ug. Predicted bind size: 22KD. Observed bind size: 22KD

background :

PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

competitor equivalent skus :

sc 137150 sc 137212 sc 137222 sc 23965 sc 23969 sc 23970 sc 271020 sc 271047 sc 33571 sc 33574 sc 373961 sc 373962 sc 59656 sc 59657 sc 7381

research category :

Atherosclerosis, Cardiovascular, Cell Biology, Metabolism, Oxidative Stress, Pathways And Processes, Redox Metabolism, Vascular Inflammation

synonyms :

Peroxiredoxin-1;1.11.1.15;Natural killer cell-enhancing factor A;NKEF-A;Proliferation-associated gene protein;PAG;Thioredoxin peroxidase 2;Thioredoxin-dependent peroxide reductase 2;PRDX1;PAGA, PAGB, TDPX2;

gene full name :

Peroxiredoxin-1

molecular weight :

22110 MW

protein function :

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

subcellular localization :

Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

protein name :

Peroxiredoxin-1

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

sequence similarities :

Belongs to the AhpC/TSA family.

last modified :

1/28/19 19:39