Anti-MAG Antibody | Boster PA1751-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-MAG Antibody

catalog :

PA1751-1

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

PA1751-1

status :

Enabled

name :

Anti-MAG Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

MAG

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for SIGLEC 4A/MAG detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. SIGLEC 4A/MAG information: Molecular Weight: 69069 MW; Subcellular Localization: Membrane; Single-pass type I membrane protein.

short description :

Rabbit IgG polyclonal antibody for Myelin-associated glycoprotein(MAG) detection. Tested with WB in Human;Mouse;Rat.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

P20916

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human MAG(611-626aa YTLTEELAEYAEIRVK), identical to the related mouse and rat sequences.

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Human, Mouse, Rat.

applications :

reactivity :

Human, Mouse, Rat

predicted reactivity :

Hamster

image labels :

Anti-MAG antibody, PA1751-1, All Western blotting. All lanes: Anti-MAG(PA1751-1) at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug. Lane 2: Mouse Brain Tissue Lysate at 40ug. Predicted bind size: 69KD. Observed bind size: 100KD

background :

MAG(Myelin-associated glycoprotein),also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney(HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.

competitor equivalent skus :

sc 9543 sc 15324 sc 373999 sc 166780 sc 166921 sc 376145 sc 9542 sc 9544 sc 166849

research category :

Cell Adhesion Proteins, Membrane Proteins, Neurogenesis, Neurology Process, Neuroscience

synonyms :

Myelin-associated glycoprotein;Siglec-4a;MAG;GMA;

gene full name :

Myelin-associated glycoprotein

molecular weight :

69069 MW

protein function :

Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity).

subcellular localization :

Membrane; Single-pass type I membrane protein.

protein name :

Myelin-associated glycoprotein

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

sequence similarities :

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

last modified :

1/28/19 19:39