antibody

Anti-TGF beta Receptor I/TGFBR1 Antibody

PA1731

100 ug/vial

polyclonal

domestic rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Enabled

Anti-TGF beta Receptor I/TGFBR1 Antibody

Primary Antibodies, Polyclonal Antibodies, IHC ICC IF Antibodies

TGFBR1

30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280

Polyclonal

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

No

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Polyclonal antibody for TGF BETA RECEPTOR I/TGFBR1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. TGF BETA RECEPTOR I/TGFBR1 information: Molecular Weight: 55960 MW; Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction; Tissue Specificity: Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.

Rabbit IgG polyclonal antibody for TGF-beta receptor type-1(TGFBR1) detection. Tested with WB, IHC-P in Human;Rat;Mouse.

100 ug/vial

30ug for $99, contact us for details

P36897

Rabbit

A synthetic peptide corresponding to a sequence in the middle region of human TGFBR1 (281-295aa DYHEHGSLFDYLNRY), identical to the related rat and mouse sequences.

Lyophilized

Immunogen affinity purified.

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

No cross reactivity with other proteins

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat . Western blot, 0.1-0.5ug/ml, Human, Mouse, Rat.

IHC, WB

Human, Mouse, Rat

Hamster

Anti-TGFBR1 antibody, PA1731, Western blotting. All lanes: Anti TGFBR1 (PA1731) at 0.5ug/ml. Lane 1: Human Placenta Tissue Lysate at 50ug. Lane 2: HELA Whole Cell Lysate at 40ug. Predicted bind size: 56KD. Observed bind size: 56KD Anti-TGFBR1 antibody, PA1731, IHC(P). IHC(P): Human Mammary Cancer Tissue

TGFBR1, Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome(LDAS). TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss(1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.

sc 137639 sc 137638 sc 137640

Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Growth Factors, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways And Processes, Response To Hypoxia, Signal Transduction, Signaling Pathways, Stem Cells, Surface Molecules, Tgf Beta

TGF-beta receptor type-1;TGFR-1;2.7.11.30;Activin A receptor type II-like protein kinase of 53kD;Activin receptor-like kinase 5;ALK-5;ALK5;Serine/threonine-protein kinase receptor R4;SKR4;TGF-beta type I receptor;Transforming growth factor-beta receptor type I;TGF-beta receptor type I;TbetaR-I;TGFBR1;ALK5, SKR4;

TGF-beta receptor type-1

55960 MW

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.

Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.

TGF-beta receptor type-1(TGFR-1)

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

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