Anti-sE-Selectin Antibody | Boster PA1704 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-sE-Selectin Antibody

catalog :

PA1704

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

product information

sku :

PA1704

name :

Anti-sE-Selectin Antibody

price :

200 USD

immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human CD62E(33-50aa YDEASAYCQQRYTHLVAI), different from the related rat and mouse sequences by two amino acids.

form :

Lyophilized

host :

Rabbit

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

purification :

Immunogen affinity purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for E-selectin(SELE) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

size :

100 ug/vial

reactivity :

Human; Mouse; Rat

applications :

IHC-P; WB

background :

E-Selectin(SELE), also called Selectin E, ELAM1 or ELAM, is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. It is though to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. E-Selection is a member of the selectin family of cell adhesion molecules. The E-Selectin gene is mapped on 1q24.2. The ELAM gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA by Collins et al. Using affinity chromatography, pull-down assays, and mass spectrometric analysis on adenocarcinoma cell lines, Gout et al. showed that SELE bound death receptor-3 on the cancer cells. Western blot analysis revealed that the SELE-binding protein was recognized by anti-DR3 antibodies. Anti-DR3 or knockdown of DR3 by small interfering RNA decreased adhesion of colon cancer cells to SELE and to SELE-expressing endothelial cells.

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cross reactivity :

No cross reactivity with other proteins

gene full name :

E-selectin

gene name :

SELE

predicted reactivity :

Hamster

protein function :

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

protein name :

E-selectin

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

research category :

neuroscience neurology process neurodegenerative disease signal transduction metabolism vitamins / minerals cancer oncoproteins/suppressors tumor suppressors metabolism pathways and processes cofactors, vitamins / minerals types of disease

sequence similarities :

Belongs to the selectin/LECAM family.

storage :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Cell membrane ; Single-pass type I membrane protein.

synonyms :

E-selectin;CD62 antigen-like family member E;Endothelial leukocyte adhesion molecule 1;ELAM-1;Leukocyte-endothelial cell adhesion molecule 2;LECAM2;CD62E;SELE;ELAM1;

uniprot id :

P16581