Anti-Integrin beta 4/ITGB4 Antibody | Boster PA1702-2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Integrin beta 4/ITGB4 Antibody

catalog :

PA1702-2

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

sku :

PA1702-2

status :

Enabled

name :

Anti-Integrin beta 4/ITGB4 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

ITGB4

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for CD104/ITGB4 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. CD104/ITGB4 information: Molecular Weight: 202167 MW; Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes; Tissue Specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

short description :

Rabbit IgG polyclonal antibody for Integrin beta-4(ITGB4) detection. Tested with WB in Human.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

P16144

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin beta 4(422-437aa HVCQLPEDQKGNIHLK).

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Human.

applications :

reactivity :

Human

predicted reactivity :

Chicken

image labels :

Anti- ITGB4 antibody, PA1702-2, Western blotting. All lanes: Anti ITGB4 (PA1702-2) at 0.5ug/ml. WB: A431 Whole Cell Lysate at 40ug. Predicted bind size: 200KD. Observed bind size: 200KD

background :

ITGB4(Integrin, beta-4), also known as CD104(Cluster of Differentiation 104), is a human gene. The gene encodes the integrin beta 4 subunits, a receptor for the laminins. This subunit tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma. The ITGB4 gene is mapped on 17q25.1. Using expression profiling, Yang et al. found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells. They confirmed that ZKSCAN3 bound the promoter of ITGB4 in vitro and in vivo. ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines. The integrin beta-4 subunit is characterized by an unusually long cytoplasmic domain that harbors 4 fibronectin type III(FNIII) repeats, residing in 2 pairs separated by a connecting segment. Vidal et al. found compound heterozygosity for mutations in the ITGB4 gene in an infant with junctional epidermolysis bullosa associated with pyloric atresia.

competitor equivalent skus :

sc 162284 sc 162283 sc 162282

research category :

Cell Adhesion, Cytoskeleton / Ecm, Integrins, Signal Transduction

synonyms :

Integrin beta-4;GP150;CD104;ITGB4;

gene full name :

Integrin beta-4

molecular weight :

202167 MW

protein function :

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

subcellular localization :

Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.

tissue specificity :

Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

protein name :

Integrin beta-4

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

sequence similarities :

Belongs to the integrin beta chain family.

last modified :

1/28/19 19:39