Anti-GRIA2 Antibody | Boster PA1598 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-GRIA2 Antibody

catalog :

PA1598

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

product information

sku :

PA1598

name :

Anti-GRIA2 Antibody

price :

200 USD

immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human GRIA2 (260-277aa FQIVDYDDSLVSKFIERW), identical to the related rat and mouse sequences.

form :

Lyophilized

host :

Rabbit

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

purification :

Immunogen affinity purified.

clonality :

Polyclonal

description :

Rabbit IgG polyclonal antibody for Glutamate receptor 2(GRIA2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

size :

100 ug/vial

reactivity :

Human; Mouse; Rat

applications :

IHC-P; WB

background :

GLUR2, also called Glutamate receptors and mediated by a G-protein that inhibits adenylate cyclase activity, sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate(AMPA), are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. GLUR2's cytogenetic location is 4q32.1. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. As previously demonstrated in rats, the GLUR2 in human has RNA editing, posttranscriptional change of the sequence at the mRNA level. And interruption of the interaction between C-terminal Glur2 and PDZ domain-containing proteins, such as GRIP and PICK1, resulted in increased AMPA receptor-mediated excitatory transmission and blockade of long-term depression.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse.

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

cross reactivity :

No cross reactivity with other proteins

gene full name :

Glutamate receptor 2

gene name :

GRIA2

predicted reactivity :

Hamster

protein function :

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

protein name :

Glutamate receptor 2(GluR-2)

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

research category :

GRIA2

storage :

At -20ËšC for one year. After reconstitution, at 4ËšC for one month. It can also be aliquotted and stored frozen at -20ËšC for a longer time.Avoid repeated freezing and thawing.

subcellular localization :

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

synonyms :

Glutamate receptor 2;GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic, AMPA 2;GluA2;GRIA2;GLUR2;

uniprot id :

P42262