Anti-Glutamate Receptor 1/GRIA1 Antibody | Boster PA1587 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Glutamate Receptor 1/GRIA1 Antibody

catalog :

PA1587

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

PA1587

status :

Enabled

name :

Anti-Glutamate Receptor 1/GRIA1 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

GRIA1

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for GluR1/GRIA1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. GluR1/GRIA1 information: Molecular Weight: 101506 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendrite . Cell projection, dendritic spine . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression; Tissue Specificity: Widely expressed in brain.

short description :

Rabbit IgG polyclonal antibody for Glutamate receptor 1(GRIA1) detection. Tested with WB in Human;Mouse;Rat.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

P42261

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human GRIA1 (881-895aa HDFPKSMQSIPCMSH), different from the related rat and mouse sequences by one amino acid.

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Rat, Human, Mouse.

applications :

reactivity :

Human, Mouse, Rat

predicted reactivity :

Chicken

image labels :

Anti- GRIA1 antibody, PA1587, Western blotting. All lanes: Anti GRIA1 (PA1587) at 0.5ug/ml. WB: Rat Brain Tissue Lysate at 50ug. Predicted bind size: 101KD. Observed bind size: 101KD

background :

GLUR1, Glutamate receptor 1, is a protein that in humans is encoded by the GLUR1 gene. The sequence of GLUR1 was predicted to encode a 907-amino acid protein that had 97% identity to one of the rodent kainate receptor subunits. GLUR1 mRNA is widely expressed in human brain. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA) receptors. Each of the members(GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.

competitor equivalent skus :

sc 101688 sc 12624 sc 12624 R sc 13152 sc 135698 sc 135699 sc 16313 sc 16313 R sc 16314 sc 16314 R sc 26472 sc 28799 sc 33612 sc 55509 sc 7609

research category :

Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels

synonyms :

Glutamate receptor 1;GluR-1;AMPA-selective glutamate receptor 1;GluR-A;GluR-K1;Glutamate receptor ionotropic, AMPA 1;GluA1;GRIA1;GLUH1, GLUR1;

gene full name :

Glutamate receptor 1

molecular weight :

101506 MW

protein function :

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

subcellular localization :

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendrite . Cell projection, dendritic spine . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

tissue specificity :

Widely expressed in brain.

protein name :

Glutamate receptor 1(GluR-1)

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

last modified :

1/28/19 19:39