Anti-STAT2 Antibody | Boster PA1509 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-STAT2 Antibody

catalog :

PA1509

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

sku :

PA1509

status :

Enabled

name :

Anti-STAT2 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

STAT2

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for STAT2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. STAT2 information: Molecular Weight: 97916 MW; Subcellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

short description :

Rabbit IgG polyclonal antibody for Signal transducer and activator of transcription 2(STAT2) detection. Tested with WB in Human.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

P52630

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human STAT2(796-814aa RHLNTEPMEIFRNCVKIEE).

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Human.

applications :

reactivity :

Human

predicted reactivity :

Monkey

image labels :

Anti-STAT2 antibody, PA1509, Western blotting. Lane 1: U87 Cell Lysate. Lane 2: U87 Cell Lysate. Lane 3: U87 Cell Lysate. Lane 4: U87 Cell Lysate.

background :

Signal transducer and activator of transcription 2(STAT2) is a protein that in humans is encoded by the STAT2 gene. The protein encoded by this gene is a member of the STAT protein family. The International Radiation Hybrid Mapping Consortium mapped the STAT2 gene to chromosome 12. STAT2 is a transcription factor critical to the signal transduction pathway of type I interferons. ISGF3(STAT2) assembly involves p48 functioning as an adaptor protein to recruit Stat1 and Stat2 to an IFN-alpha-stimulated response element, Stat2 contributes a potent transactivation domain but is unable to directly contact DNA, while Stat1 stabilizes the heteromeric complex by contacting DNA directly.

competitor equivalent skus :

sc 839 sc 950 sc 22816 sc 476 sc 166201 sc 1668 sc 136079 sc 950 X sc 22816 X sc 514193 sc 166201 X sc 839 X sc 476 X sc 514193 X sc 1668 X

research category :

Epigenetics And Nuclear Signaling, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

synonyms :

Signal transducer and activator of transcription 2;p113;STAT2;

gene full name :

Signal transducer and activator of transcription 2

molecular weight :

97916 MW

protein function :

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

subcellular localization :

Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

protein name :

Signal transducer and activator of transcription 2

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

sequence similarities :

Belongs to the transcription factor STAT family.

last modified :

1/28/19 19:39