Anti-APPL/APPL1 Antibody | Boster PA1389 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-APPL/APPL1 Antibody

catalog :

PA1389

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

sku :

PA1389

status :

Enabled

name :

Anti-APPL/APPL1 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies, IHC ICC IF Antibodies

gene name :

APPL1

price various sizes :

30ug sample size / $99 100ug / $280 100ug+Free HRP Secondary BA1054 / $280 100ug+Free Biotin Secondary BA1003 / $280

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for APPL/APPL1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IHC-P. Reactive species: Human. APPL/APPL1 information: Molecular Weight: 79663 MW; Subcellular Localization: Early endosome membrane; Peripheral membrane protein. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF; Tissue Specificity: High levels in heart, ovary, pancreas and skeletal muscle.

short description :

Rabbit IgG polyclonal antibody for DCC-interacting protein 13-alpha(APPL1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

Q9UKG1

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human APPL(138-158aa NDHDAAINRYSRLSKKRENDK), identical to the related mouse and rat sequences.

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Immunohistochemistry(Paraffin-embedded Section), 0.5-1ug/ml, Rat, Human, Mouse, By Heat. Western blot, 0.1-0.5ug/ml, Human, Rat, Mouse.

applications :

IHC, WB

reactivity :

Human, Mouse, Rat

predicted reactivity :

Hamster

image labels :

Anti-APPL antibody, PA1389, Western blotting. WB: HELA Cell Lysate

background :

DCC-interacting protein 13-alpha(APPL1) is a protein that in humans is encoded by the APPL1 gene. The APPL1 gene is mapped to 3q21.1-p13.3. It is said to contain 709 amino acids and share 54% amino acid identity with APPL2. APPL is highly expressed in skeletal muscle, heart, ovary, and pancreas, tissues in which AKT2 mRNA is abundant. It has been regarded as an adaptor that may tether inactive AKT2 to the PI3K in the cytoplasm and thereby may expedite recruitment of AKT2 and PI3K to the cell membrane upon mitogenic stimulation.

competitor equivalent skus :

sc 55065 sc 67402 sc 271909 sc 55063 sc 271901

research category :

Adapters, Apoptosis, Associated Proteins, Cell Biology, Cytoplasmic, Developmental Biology, Intracellular, Nervous System Development, Neural Signal Transduction, Neurogenesis, Neurology Process, Neuroscience, Organelle Proteins, Organogenesis, Protein Trafficking, Signal Transduction

synonyms :

DCC-interacting protein 13-alpha;Dip13-alpha;Adapter protein containing PH domain, PTB domain and leucine zipper motif 1;APPL1;APPL , DIP13A, KIAA1428 ;

gene full name :

DCC-interacting protein 13-alpha

molecular weight :

79663 MW

protein function :

Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.

subcellular localization :

Early endosome membrane; Peripheral membrane protein. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.

tissue specificity :

High levels in heart, ovary, pancreas and skeletal muscle.

protein name :

DCC-interacting protein 13-alpha(Dip13-alpha)

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

sequence similarities :

Contains 1 PH domain.

last modified :

1/28/19 19:39