Anti-SOCS2 Antibody | Boster PA1383 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-SOCS2 Antibody

catalog :

PA1383

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

PA1383

status :

Enabled

name :

Anti-SOCS2 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

SOCS2

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for SOCS-2/SOCS2 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. SOCS-2/SOCS2 information: Molecular Weight: 22172 MW; Tissue Specificity: High expression in heart, placenta, lung, kidney and prostate.

short description :

Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human;Mouse;Rat.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

O14508

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS2(181-198aa LPLPTRLKDYLEEYKFQV), identical to the related mouse and rat sequences.

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Human, Mouse, Rat.

applications :

reactivity :

Human, Mouse, Rat

predicted reactivity :

Bovine

image labels :

Anti-SOCS2 antibody, PA1383, Western blotting. All lanes: Anti SOCS2 (PA1383) at 0.5ug/ml. Lane 1: Rat Liver Tissue Lysate at 50ug. Lane 2: Rat Spleen Tissue Lysate at 50ug. Lane 3: MCF-7 Whole Cell Lysate at 40ug. Lane 4: HELA Whole Cell Lysate at 40ug. Lane 5: SMMC Whole Cell Lysate at 40ug. Lane 6: HT1080 Tissue Lysate at 50ug. Lane 7: Mouse Cardiac Muscle Tissue Lysate at 50ug. Lane 8: Mouse Liver Tissue Lysate at 50ug. Lane 9: Mouse Spleen Tissue Lysate at 50ug. Predicted bind size: 22KD. Observed bind size: 22KD

background :

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signalling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma(IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor(IGF1R), and thus is though to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al.(1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

competitor equivalent skus :

sc 7007 sc 7007 R sc 7008 sc 9022

research category :

Adapters, Cytokines, Cytoplasmic, Immunology, Innate Immunity, Neural Signal Transduction, Neurology Process, Neuroscience, Signal Transduction

synonyms :

Suppressor of cytokine signaling 2;SOCS-2;Cytokine-inducible SH2 protein 2;CIS-2;STAT-induced STAT inhibitor 2;SSI-2;SOCS2;CIS2, SSI2, STATI2;

gene full name :

Suppressor of cytokine signaling 2

molecular weight :

22172 MW

protein function :

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

tissue specificity :

High expression in heart, placenta, lung, kidney and prostate.

protein name :

Suppressor of cytokine signaling 2(SOCS-2)

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

sequence similarities :

Contains 1 SH2 domain.

last modified :

1/28/19 19:39