Anti-Apolipoprotein A I/APOA1 Antibody | Boster PA1247 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Apolipoprotein A I/APOA1 Antibody

catalog :

PA1247

quantity :

100 ug/vial

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

sku :

PA1247

status :

Enabled

name :

Anti-Apolipoprotein A I/APOA1 Antibody

category name :

Primary Antibodies, Polyclonal Antibodies

gene name :

APOA1

price various sizes :

30ug sample size / $99 100ug / $240 100ug+Free HRP Secondary BA1054 / $240 100ug+Free Biotin Secondary BA1003 / $240

clonality :

Polyclonal

concentration :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

conjugate :

contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

description :

Polyclonal antibody for APOA I/APOA1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: WB. Reactive species: Human. APOA I/APOA1 information: Molecular Weight: 30778 MW; Subcellular Localization: Secreted; Tissue Specificity: Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

short description :

Rabbit IgG polyclonal antibody for Apolipoprotein A-I(APOA1) detection. Tested with WB in Human;Mouse;Rat.

size :

100 ug/vial

sample size available :

30ug for $99, contact us for details

uniprot id :

P02647

host :

Rabbit

immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human APOA1 (42-58aa YVDVLKDSGRDYVSQFE), different from the related mouse and rat sequences by two amino acids.

form :

Lyophilized

purification :

Immunogen affinity purified.

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

cross reactivity :

No cross reactivity with other proteins

reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

application details :

Western blot, 0.1-0.5ug/ml, Human, Rat, Mouse.

applications :

reactivity :

Human, Mouse, Rat

image labels :

Anti-APOA1 antibody, PA1247, Western blotting. Lane 1: MCF-7 Cell Lysate. Lane 2: HELA Cell Lysate. Lane 3: MM453 Cell Lysate. Lane 4: SMMC Cell Lysate. Lane 5: HT1080 Cell Lysate.

background :

Apolipoprotein A-1, also known as APOA1, is a human protein with a specific role in lipid metabolism. It binds to lipopolysaccharide or endotoxin, and has a major role in the anti-endotoxin function of HDL. The gene is mapped to 11q23. And it is a single polypeptide chain with 243 amino acid residues of known primary amino acid sequence. The ApoA-I protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase(LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin(PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.Additionally, ApoA-I overexpression promotes macrophage-specific reverse cholesterol transport.

competitor equivalent skus :

sc 19029 sc 23605 sc 30089 sc 376811 sc 376818 sc 58230 sc 69755 sc 80551

research category :

Cardiovascular, Cholesterol Metabolism, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Lipids / Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Signal Transduction

synonyms :

Apolipoprotein A-I;Apo-AI;ApoA-I;Apolipoprotein A1;Proapolipoprotein A-I;ProapoA-I;Truncated apolipoprotein A-I;Apolipoprotein A-I(1-242);APOA1;

gene full name :

Apolipoprotein A-I

molecular weight :

30778 MW

protein function :

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

subcellular localization :

Secreted.

tissue specificity :

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

protein name :

Apolipoprotein A-I(Apo-AI/ApoA-I)

recommended detection systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.

sequence similarities :

Belongs to the apolipoprotein A1/A4/E family.

last modified :

1/28/19 19:39