Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody

catalog :

P02533

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

FDE-3

reactivity :

human

application :

western blot, immunocytochemistry

product information

SKU :

P02533

Product Name :

Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

FDE-3

Host :

Rabbit

Reactivity :

Human

Application(s) :

IF, ICC, WB

Application Details :

WB 1:1000-1:2000 .ICC/IF 1:50-1:200

Description :

Boster Bio Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody catalog # P02533. Tested in IF, ICC, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CRK

Uniprot ID :

P46108

Immunogen :

A synthesized peptide derived from human Phospho-CrkII (Tyr221)

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Adapter molecule crk

Synonyms :

Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK;

Molecular Weight :

33831 MW

Protein Function :

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Subcellular Localization :

Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion.

Research Category :

Adapters, Cancer, Cytoplasmic, Signal Transduction