Anti-Phospho-IL-7 Receptor Alpha Chain Y449 Antibody | Boster P02222 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-IL-7 Receptor Alpha Chain Y449 Antibody

catalog :

P02222

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot

product information

SKU :

P02222

Product Name :

Anti-Phospho-IL-7 Receptor Alpha Chain Y449 Antibody

Size :

100 ug

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Application Details :

Western Blot, 1:10, 000, human, mouse, rat.Direct ELISA, 1:5, 000-1:50, 000, human, mouse, ratImmunohistochemistry: User Optimized, human, mouse, rat.

Description :

Boster Bio Anti-Phospho-IL-7 Receptor Alpha Chain Y449 Antibody catalog # P02222. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

0.72 mg/mL by UV absorbance at 280 nm

Gene Name :

IL7R

Uniprot ID :

P16871

Form :

Liquid

Gene Full Name :

Interleukin-7 receptor subunit alpha

Synonyms :

Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127; CD127; IL7R;

Molecular Weight :

51581 MW

Protein Function :

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Background :

The interleukin-7 receptor, also known as IL7R alpha, is a protein found on the surface of cells. It is mapped to 5p13. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V (D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).

Research Category :

Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Interleukins, Lymphoid, Myeloid, Stem Cells, T Lymphocytic Lineage