Anti-Phospho-PP2A alpha (Y307) PPP2CA Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-PP2A alpha (Y307) PPP2CA Rabbit Monoclonal Antibody

catalog :

P01893

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

AAA-16

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

SKU :

P01893

Product Name :

Anti-Phospho-PP2A alpha (Y307) PPP2CA Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

AAA-16

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

IP, IF, IHC, ICC, WB

Application Details :

WB 1:500-1:2000 .IHC 1:50-1:200 .ICC/IF 1:50-1:200 .IP 1:50 .

Description :

Boster Bio Anti-Phospho-PP2A alpha (Y307) PPP2CA Rabbit Monoclonal Antibody catalog # P01893. Tested in IP, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

PPP2CA

Uniprot ID :

P67775

Immunogen :

A synthesized peptide derived from human Phospho-PP2A alpha (Y307)

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Synonyms :

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; 3.1.3.16; Replication protein C; RP-C; PPP2CA;

Molecular Weight :

35594 MW

Protein Function :

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

Subcellular Localization :

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity).

Research Category :

Cancer, Cardiovascular, Cell Biology, Cell Cycle, Contractility, Cytoplasmic, Epigenetics and Nuclear Signaling, Intracellular Signaling, Kinases/Phosphatases, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser / Thr Phosphatases, Signal Transduction, Signaling Pathways, Stem Cells, Tgf Beta