Anti-Phospho-IKB alpha (S32) NFKBIA Rabbit Monoclonal Antibody

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-IKB alpha (S32) NFKBIA Rabbit Monoclonal Antibody

catalog :

P01139

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EDG-14

reactivity :

human

application :

western blot, immunoprecipitation

product information

SKU :

P01139

Product Name :

Anti-Phospho-IKB alpha (S32) NFKBIA Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

EDG-14

Host :

Rabbit

Reactivity :

Human

Application(s) :

IP, WB

Application Details :

WB 1:500-1:2000 .IP 1:50

Description :

Boster Bio Anti-Phospho-IKB alpha (S32) NFKBIA Rabbit Monoclonal Antibody catalog # P01139. Tested in IP, WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

NFKBIA

Uniprot ID :

P25963

Immunogen :

A synthesized peptide derived from human Phospho-IKB alpha (S32)

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

NF-kappa-B inhibitor alpha

Synonyms :

NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3; NFKBIA; IKBA, MAD3, NFKBI;

Molecular Weight :

35609 MW

Protein Function :

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Subcellular Localization :

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.

Research Category :

Cancer, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Nfkb Pathway, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Tlr Signaling