Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody

catalog :

P00683

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EGH-5

reactivity :

human

application :

western blot

product information

SKU :

P00683

Product Name :

Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

EGH-5

Host :

Rabbit

Reactivity :

Human

Application(s) :

Application Details :

WB 1:500-1:2000

Description :

Boster Bio Anti-Phospho-IRE1 (S724) ERN1 Rabbit Monoclonal Antibody catalog # P00683. Tested in WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

ERN1

Uniprot ID :

O75460

Immunogen :

A synthesized peptide derived from human Phospho-IRE1 (S724)

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Serine/threonine-protein kinase/endoribonuclease IRE1

Synonyms :

Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a; Serine/threonine-protein kinase; 2.7.11.1; Endoribonuclease; 3.1.26.-; ERN1 ; IRE1 ;

Molecular Weight :

109735 MW

Protein Function :

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Subcellular Localization :

Endoplasmic reticulum membrane ; Single-pass type I membrane protein.

Tissue Specificity :

Ubiquitously expressed. High levels observed in pancreatic tissue.

Research Category :

Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction