Anti-Phospho-Rac1/Cdc42 (Ser71) Rabbit Monoclonal Antibody

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-Rac1/Cdc42 (Ser71) Rabbit Monoclonal Antibody

catalog :

P00119

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

IBB-3

reactivity :

human

application :

western blot

product information

SKU :

P00119

Product Name :

Anti-Phospho-Rac1/Cdc42 (Ser71) Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

IBB-3

Host :

Rabbit

Reactivity :

Human

Application(s) :

Application Details :

WB 1:500-1:1000

Description :

Boster Bio Anti-Phospho-Rac1/Cdc42 (Ser71) Rabbit Monoclonal Antibody catalog # P00119. Tested in WB applications. This antibody reacts with Human.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CDC42

Uniprot ID :

P60953

Immunogen :

A synthesized peptide derived from human Phospho-Rac1/Cdc42 (Ser71)

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Cell division control protein 42 homolog

Synonyms :

Cell division control protein 42 homolog; G25K GTP-binding protein; CDC42;

Molecular Weight :

21259 MW

Protein Function :

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Subcellular Localization :

Cell membrane ; Lipid-anchor ; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.

Research Category :

Cancer, Cell Biology, Cell Cycle, Cell Division, Cytokinesis, Epigenetics and Nuclear Signaling, G Protein Signaling, Kinases/Phosphatases, Protein Trafficking, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins, Vesicle Transport