Anti-Phospho-Tau (Ser416) Antibody | Boster P00097 product information

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product summary

company name :

Boster

product type :

other

product name :

Anti-Phospho-Tau (Ser416) Antibody

catalog :

P00097

quantity :

100 ul

product information

sku :

P00097

status :

Enabled

name :

Anti-Phospho-Tau (Ser416) Antibody

category name :

Primary Antibodies, Polyclonal Antibodies, IHC ICC IF Antibodies

gene name :

MAPT

price various sizes :

100ul / $300 100ul+Free HRP Secondary BA1054 / $300 100ul+Free Biotin Secondary BA1003 / $300

clonality :

Polyclonal

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.

description :

Polyconal antibody for Tau/MAPT detection. Host: Rabbit.Size: 100ul. Tested applications: IHC. Reactive species: Mouse. Tau/MAPT information: Molecular Weight: 78928 MW; Subcellular Localization: Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components; Tissue Specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

short description :

Phospho-specific Rabbit Anti-Tau (Ser 416 ) Antibody tested for IHC, WB in mouse, rat.

size :

100 ul

uniprot id :

P10636

host :

Rabbit

immunogen :

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of rat tau.

form :

Liquid

storage :

At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquotted and stored frozen at -20 C for a longer time.Avoid repeated freezing and thawing.

application details :

WB, 1:1, 000

applications :

reactivity :

Mouse, Rat

predicted reactivity :

Bovine, Canine, Human

image labels :

Western blot of rat brain homogenate showing specific immunolabeling of the ~59 kDa, ~65 kDa,~ 68 kDa Tau isoforms phosphorylated at Ser 416 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide (not shown).

research category :

Alzheimer'S Disease, Cell Type Marker, Cytoskeleton, Cytoskeleton / Ecm, Microtubules, Neurodegenerative Disease, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction

synonyms :

Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;MAPT;MAPTL, MTBT1, TAU;

gene full name :

Microtubule-associated protein tau

molecular weight :

78928 MW

protein function :

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

subcellular localization :

Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

tissue specificity :

Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

protein name :

Microtubule-associated protein tau

last modified :

2/6/19 22:57