Anti-Phospho-Smad2 (S250) Rabbit Monoclonal Antibody | Boster P00090-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-Smad2 (S250) Rabbit Monoclonal Antibody

catalog :

P00090-1

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HBC-19

reactivity :

human, mouse, rat

application :

western blot, flow cytometry

product information

SKU :

P00090-1

Product Name :

Anti-Phospho-Smad2 (S250) Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

HBC-19

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Flow Cytometry, WB

Application Details :

WB 1:1000-1:2000 .Flow Cytometry 1:20

Description :

Boster Bio Anti-Phospho-Smad2 (S250) Rabbit Monoclonal Antibody catalog # P00090-1. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

SMAD2

Uniprot ID :

Q15796

Immunogen :

A synthesized peptide derived from human Smad2

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Mothers against decapentaplegic homolog 2

Synonyms :

Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD2; MADH2, MADR2;

Molecular Weight :

52306 MW

Protein Function :

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Subcellular Localization :

Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.

Tissue Specificity :

Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

Research Category :

Cancer, Cytoplasmic, Epigenetics and Nuclear Signaling, Growth Factors, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Stem Cells, Tgf Beta