Anti-Phospho-STAT3 Y705 Antibody | Boster P00007 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-Phospho-STAT3 Y705 Antibody

catalog :

P00007

quantity :

100 ug

price :

298 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

product information

sku :

P00007

name :

Anti-Phospho-STAT3 Y705 Antibody

price :

298 USD

form :

Liquid

host :

Rabbit

clonality :

Polyclonal

description :

Anti-STAT3 phospho Y705 Antibody validated for WB in Human.

size :

100 ug

reactivity :

Human

applications :

IHC; WB

background :

The transcription factor, signal transducer and activator of transcription-3(STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription(STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21, it contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.

concentration :

1.0 mg/mL by UV absorbance at 280 nm

gene full name :

Signal transducer and activator of transcription 3

gene name :

STAT3

protein function :

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

research category :

signal transduction signaling pathway nuclear signaling stats epigenetics and nuclear signaling transcription other factors stem cells embryonic stem cells intracellular nuclear signaling pathways cancer stat family cardiovascular heart cardiogenesis transcription factors/regulators hypertrophy transcription factors developmental biology embryogenesis surface molecules

subcellular localization :

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

synonyms :

Signal transducer and activator of transcription 3;Acute-phase response factor;STAT3;APRF;

tissue specificity :

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

uniprot id :

P40763