Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19) | Boster MA1079 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19)

catalog :

MA1079

quantity :

100μg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CH-19

The same clone is also sold as:

MilliporeSigma: C1821
Abnova: MAB1477
Santa Cruz Biotechnology: sc-59876

reactivity :

human, mouse, rat, chicken

application :

western blot, immunohistochemistry

product information

SKU :

MA1079

Product Name :

Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19)

Size :

100μg/vial

Clonality :

Monoclonal

Clone Number :

CH-19

Host :

Mouse

Reactivity :

Chicken, Human, Mouse, Rabbit, Rat, Snake

Application(s) :

IHC, WB

Application Details :

Immunohistochemistry (Paraffin-embedded Section), 2-4µg/ml, Human, mouse, rat, rabbit, chicken, snake., By Heat. Western blot, 1-2µg/ml, Human, mouse, rat, rabbit, chicken, snake.

Application Notes :

Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19) catalog # MA1079. Tested in IHC, WB applications. This antibody reacts with Chicken, Human, Mouse, Rabbit, Rat, Snake.

Concentration :

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Gene Name :

CDH1; CDH2; CDH3

Uniprot ID :

F1LMI3

Immunogen :

Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH.

Form :

Lyophilized

Contents :

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Purification :

Ascites

Cross-reactivity :

No cross reactivity with other proteins

Isotype :

Mouse IgG1

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Gene Full Name :

cadherin 1, type 1, E-cadherin(epithelial); cadherin 2, type 1, N-cadherin(neuronal); cadherin 3, type 1, P-cadherin(placental)

Synonyms :

Cadherin 3, type 1, P-cadherin (Placental) ; Protein Cdh3 ; Cdh3 ; rCG_51631 ;

Protein Name :

Cadherin-1; Cadherin-2; Cadherin-3

Molecular Weight :

90415 MW

Protein Function :

Cadherins are calcium-dependent cell adhesion proteins.

Subcellular Localization :

CDH1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome. Golgi apparatus, trans-Golginetwork. Note: Colocalizes with DLGAP5 at sites of cell-cellcontact in intestinal epithelial cells. Anchored to actinmicrofilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calciuminflux, results in translocation from sites of cell-cell contactto the cytoplasm. Colocalizes with RAB11A endosomes during itstransport from the Golgi apparatus to the plasma membrane. Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). Cdh1: Cell junction. Cell membrane; Single-passtype I membrane protein. Endosome Golgi apparatus,trans-Golgi network Note: Colocalizes with DLGAP5 atsites of cell-cell contact in intestinal epithelial cells.Anchored to actin microfilaments through association with alpha-,beta- and gamma-catenin. Sequential proteolysis induced byapoptosis or calcium influx, results in translocation from sitesof cell-cell contact to the cytoplasm. Colocalizes with RAB11Aendosomes during its transport from the Golgi apparatus to theplasma membrane (By similarity). CDH2: Cell membrane; Single-pass type I membraneprotein. Cdh2: Cell membrane; Single-pass type I membraneprotein. Cdh2: Cell membrane CDH3: Cell membrane; Single-pass type I membraneprotein. Cdh3: Cell membrane; Single-pass type I membraneprotein.

Tissue Specificity :

CDH1: Non-neural epithelial tissues.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P).

Sequence Similarities :

Contains 5 cadherin domains.

Background :

Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma.

Research Category :

Cadherins, Cell Adhesion, Cytoskeleton / Ecm, Neuroscience, Sensory System, Signal Transduction, Visual System