This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Boster
product type :
antibody
product name :
Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4)
catalog :
MA1039
quantity :
100μg/vial
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GP1.4

The same clone is also sold as:
reactivity :
human
application :
immunohistochemistry
product information
SKU :
MA1039
Product Name :
Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4)
Size :
100μg/vial
Clonality :
Monoclonal
Clone Number :
GP1.4
Host :
Mouse
Reactivity :
Human
Application(s) :
IHC
Application Details :
Immunohistochemistry (Paraffin-embedded Section), 2-4µg/ml, Human, By Heat. Immunohistochemistry (Frozen Section), 2-4µg/ml, Human.
Application Notes :
Other applications have not been tested. Optimal dilutions should be determined by end users.
Description :
Boster Bio Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4) catalog # MA1039. Tested in IHC applications. This antibody reacts with Human.
Concentration :
Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
Gene Name :
MUC1, MUC1
Uniprot ID :
P15941
Immunogen :
Human milk fat globule membranes.
Form :
Lyophilized
Contents :
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Purification :
Ascites
Cross-reactivity :
No cross reactivity with other proteins
Isotype :
Mouse IgG1
Storage :
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution :
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Gene Full Name :
Mucin-1
Synonyms :
Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD227; Mucin-1 subunit alpha; MUC1-NT; MUC1-alpha; Mucin-1 subunit beta; MUC1-beta; MUC1-CT; MUC1; PUM;
Protein Name :
Mucin-1
Molecular Weight :
122102 MW
Protein Function :
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
Subcellular Localization :
Apical cell membrane ; Single- pass type I membrane protein. Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.
Tissue Specificity :
Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.
Recommended Detection Systems :
Boster recommends HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and IHC(F).
Sequence Similarities :
Contains 1 SEA domain.
Background :
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type I transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Research Category :
Cancer, Cell Type Markers, Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tags & Cell Markers, Tumor Associated, Tumor Immunology, Tumor-Associated Antigens
company information
Boster
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
https://www.bosterbio.com
925.485.4527
headquarters: USA
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