This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Boster
product type :
antibody
product name :
Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11)
catalog :
MA1012
quantity :
100μg/vial
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
15F11

The same clone is also sold as:
reactivity :
human, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry
product information
SKU :
MA1012
Product Name :
Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11)
Size :
100μg/vial
Clonality :
Monoclonal
Clone Number :
15F11
Host :
Mouse
Reactivity :
Bovine, Human
Predicted Reactivity :
Monkey
Application(s) :
IHC, ICC, WB
Application Details :
Immunocytochemistry , 1µg/ml, Human, bovineImmunohistochemistry (Frozen Section), 4µg/ml, Human, bovine Western blot, 2µg/ml, Human, bovine.
Application Notes :
Other applications have not been tested. Optimal dilutions should be determined by end users.
Description :
Boster Bio Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 15F11) catalog # MA1012. Tested in IHC, ICC, WB applications. This antibody reacts with Bovine, Human.
Concentration :
Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
Gene Name :
JUP
Uniprot ID :
Q6P0K8
Immunogen :
Recombinant chicken plakoglobin.
Form :
Lyophilized
Contents :
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Purification :
Ascites
Cross-reactivity :
No cross reactivity with other proteins
Isotype :
Mouse IgG1
Storage :
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution :
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Gene Full Name :
Junction plakoglobin
Synonyms :
Junction plakoglobin; Jup;
Protein Name :
Junction plakoglobin
Molecular Weight :
81801 MW
Protein Function :
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Subcellular Localization :
Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form.
Recommended Detection Systems :
Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(F) and ICC.
Sequence Similarities :
Belongs to the beta-catenin family.
Background :
Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
Research Category :
Actin Etc, Cytoskeleton, Cytoskeleton / Ecm, Microfilaments, Signal Transduction
company information
Boster
3942 B Valley Ave
Pleasanton, CA 94566
boster@bosterbio.com
https://www.bosterbio.com
925.485.4527
headquarters: USA
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