Anti-Calcineurin Alpha Ppp3r1 Antibody (Monoclonal, CN-A1)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-Calcineurin Alpha Ppp3r1 Antibody (Monoclonal, CN-A1)

catalog :

MA1008

quantity :

100μg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CN-A1

The same clone is also sold as:

Abnova: MAB12449
Invitrogen: MA5-49305

reactivity :

human, rat, bovine

application :

western blot, immunohistochemistry

product information

SKU :

MA1008

Product Name :

Anti-Calcineurin Alpha Ppp3r1 Antibody (Monoclonal, CN-A1)

Size :

100μg/vial

Clonality :

Monoclonal

Clone Number :

CN-A1

Host :

Mouse

Reactivity :

Bovine, Human, Rat

Predicted Reactivity :

Bovine, Chicken, Canine, Monkey

Application(s) :

IHC, WB

Application Details :

Immunohistochemistry (Paraffin-embedded Section), 0.5-1µg/ml, Human, bovine, rat, By Heat. Western blot, 0.25-0.5µg/ml, Human, bovine, rat.

Application Notes :

Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-Calcineurin Alpha Ppp3r1 Antibody (Monoclonal, CN-A1) catalog # MA1008. Tested in IHC, WB applications. This antibody reacts with Bovine, Human, Rat.

Concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

PPP3R1

Uniprot ID :

P63100

Immunogen :

Bovine brain calcineurin.

Form :

Liquid

Contents :

Each vial contains 50% glycerol, 1.2% Sodium acetate, 1% BSA, 0.02% NaN3.

Purification :

Ascites

Cross-reactivity :

No cross reactivity with other proteins

Isotype :

Mouse IgG1

Storage :

At -20˚C for one year and at 4˚C for one month from date of receipt. Avoid repeated freezing and thawing.

Gene Full Name :

Calcineurin subunit B type 1

Synonyms :

Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; Ppp3r1; Cna2, Cnb;

Protein Name :

Calcineurin subunit B type 1

Molecular Weight :

19300 MW

Protein Function :

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Subcellular Localization :

Cytoplasm, cytosol. Cell membrane ; Lipid-anchor. Cell membrane, sarcolemma. Translocates from the cytosol to the sarcolemma in a CIB1- dependent manner during cardiomyocytes hypertrophy.

Tissue Specificity :

Isoform 2 is testis specific.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P).

Sequence Similarities :

Belongs to the calcineurin regulatory subunit family.

Background :

Calcineurin, the Ca (2+)/calmodulin-regulated protein phosphatase, first detected in skeletal muscle and brain, has been found in all cells from yeast to mammals. Calcineurin A alpha (PPP3CA),is located on human chromosomes 4, Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. Calcineurin regulates bone formation by the osteoblast.

Research Category :

Adaptive Immunity, B Cells, Calcium Signaling, Calmodulin Pathway, Immunology, Non-Cd, Protein Phosphorylation, Ser / Thr Phosphatases, Signal Transduction, Signaling Pathway