Anti-BIN1 Antibody (Monoclonal, 99D) | Boster MA1005 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-BIN1 Antibody (Monoclonal, 99D)

catalog :

MA1005

quantity :

100μg/vial

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

99D

The same clone is also sold as:

Santa Cruz Biotechnology: sc-13575
BioLegend: 655602
Rockland Immunochemicals: 200-301-E60
OriGene: TA319582

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

SKU :

MA1005

Product Name :

Anti-BIN1 Antibody (Monoclonal, 99D)

Size :

100μg/vial

Clonality :

Monoclonal

Clone Number :

99D

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Application(s) :

IHC, ICC, WB

Application Details :

Immunocytochemistry , 1µg/ml, Human, mouse, ratImmunohistochemistry (Frozen Section), 0.5µg/ml, Human, mouse, rat Western blot, 0.25µg/ml, Human, mouse, rat.

Application Notes :

Other applications have not been tested. Optimal dilutions should be determined by end users.

Description :

Boster Bio Anti-BIN1 Antibody (Monoclonal, 99D) catalog # MA1005. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Gene Name :

BIN1

Uniprot ID :

O08839

Immunogen :

Recombinant polypeptide containing amino acids 189-398 of human Bin1.

Form :

Lyophilized

Contents :

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Purification :

Ascites

Cross-reactivity :

No cross reactivity with other proteins

Isotype :

Mouse IgG2b

Storage :

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Reconstitution :

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Gene Full Name :

Myc box-dependent-interacting protein 1

Synonyms :

Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1; Bin1; Amph2, Amphl;

Protein Name :

Myc box-dependent-interacting protein 1

Molecular Weight :

64533 MW

Protein Function :

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

Subcellular Localization :

Cytoplasm. Nucleus.

Tissue Specificity :

Isoform AMPH2-1 is expressed in brain, concentrated at nerve terminals. Isoform AMPH2-2 is widely expressed.

Recommended Detection Systems :

Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(F) and ICC.

Sequence Similarities :

Contains 1 BAR domain.

Background :

BIN1 (AMPH2) is a novel human gene product with features of a tumor suppressor protein. BIN1 gene to chromosome 2q14. Loss of BIN1 expression appears to be a frequent aberration in human hepatocellular carcinomas . mutations in BIN1 cause centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic membranes, and that the functional interaction between BIN1 and DNM2 is necessary for normal muscle function and positioning of nuclei.

Research Category :

Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling, Host Virus Interaction, Interspecies Interaction, Microbiology, Oncoproteins/Suppressors, Transcription, Tumor Suppressors