Anti-UCHL3 Rabbit Monoclonal Antibody | Boster M05004 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

antibody

product name :

Anti-UCHL3 Rabbit Monoclonal Antibody

catalog :

M05004

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

BGE-21

reactivity :

human, mouse, rat

application :

western blot

product information

SKU :

M05004

Product Name :

Anti-UCHL3 Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

BGE-21

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

Application Details :

WB 1:1000-1:2000

Description :

Boster Bio Anti-UCHL3 Rabbit Monoclonal Antibody catalog # M05004. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

UCHL3

Uniprot ID :

P15374

Immunogen :

A synthesized peptide derived from human UCHL3

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Ubiquitin carboxyl-terminal hydrolase isozyme L3

Synonyms :

Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; 3.4.19.12; Ubiquitin thioesterase L3; UCHL3;

Molecular Weight :

26183 MW

Protein Function :

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB (+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Subcellular Localization :

Cytoplasm

Tissue Specificity :

Highly expressed in heart, skeletal muscle, and testis.

Research Category :

Cell Biology, Deubiquitination, Epigenetics and Nuclear Signaling, Proteasome / Ubiquitin, Proteolysis / Ubiquitin, Ubiquitin & Ubiquitin Like Modifiers