Anti-CaMKII CAMK2B Rabbit Monoclonal Antibody | Boster M03964 product information

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product summary

company name :

Boster

product type :

antibody

product name :

Anti-CaMKII CAMK2B Rabbit Monoclonal Antibody

catalog :

M03964

quantity :

100 µl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

CEC-3

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

SKU :

M03964

Product Name :

Anti-CaMKII CAMK2B Rabbit Monoclonal Antibody

Size :

100 µl

Clonality :

Monoclonal

Clone Number :

CEC-3

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Application(s) :

IF, IHC, ICC, WB

Application Details :

WB 1:500-1:2000 .IHC 1:50-1:200 .ICC/IF 1:50-1:200

Description :

Boster Bio Anti-CaMKII CAMK2B Rabbit Monoclonal Antibody catalog # M03964. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Concentration :

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Gene Name :

CAMK2B

Uniprot ID :

Q13554

Immunogen :

A synthesized peptide derived from human CaMKII

Form :

Liquid

Contents :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Purification :

Affinity-chromatography

Storage :

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Gene Full Name :

Calcium/calmodulin-dependent protein kinase type II subunit beta

Synonyms :

Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; 2.7.11.17; CAMK2B; CAM2, CAMK2, CAMKB;

Molecular Weight :

72678 MW

Protein Function :

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca (2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca (2+) transport and in fast-twitch muscle participates in the control of Ca (2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Subcellular Localization :

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side. In slow- twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Tissue Specificity :

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Research Category :

Calcium Signaling, Calmodulin Pathway, Cardiovascular, Hypertrophy, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction, Signaling Pathway